相关实验视频
Updated: Jan 17, 2026

09:49
Kupffer Cell Isolation for Nanoparticle Toxicity Testing
Published on: August 18, 2015
24.6K
库弗弗细胞是缓解血管内感染的核心
Filipe Rodolfo Moreira Borges Oliveira1, Paul Kubes
1Department of Biomedical and Molecular Sciences, Queen's University, Kingston - ON, Canada.
Current opinion in gastroenterology
|September 23, 2025
概括
库弗弗细胞 (KCs) 是肝脏的重要巨细胞,用于对抗感染. 了解病原体如何与KC相互作用,对于开发针对血管内感染的新疗法至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 肝病学 肝病学是一种肝病学.
背景情况:
- 库弗弗细胞 (KCs) 是肝脏中主要的寄居巨细胞.
- 在免疫监测和从血液中清除病原体方面,KCs起着至关重要的作用.
研究的目的:
- 本文重点介绍了库普费尔细胞对抗血管内感染的防御的重要贡献.
- 它侧重于最近关于感染中KC功能的发现.
主要方法:
- 这是一个小小的综述,综合现有研究.
- 它讨论了与KC起源,自我更新,功能性可塑性和训练免疫力相关的发现.
主要成果:
- 库弗弗细胞是最前线的响应者,细胞化微生物.
- KCs表现出了显著的功能可塑性和训练有素的免疫力.
- 然而,KCs可能会被压倒,并屈服于某些感染.
结论:
- 了解KC-病原体相互作用是改善抗感染疗法的关键.
- 未来的研究应该调查病原体逃避机制和策略,以增强KC的抗菌功能.
- 开发具有相关环境因素的人性化KC模型对于全面理解至关重要.
相关概念视频
Cells of the Innate Immune Response
8.7K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
8.7K
Immune Surveillance by NK Cells and Phagocytes
7.9K
Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
7.9K
Cell-mediated Immune Responses
83.5K
Overview
83.5K
Immune Response Against Viral Pathogens
1.8K
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
1.8K
Liver Regeneration
4.3K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
4.3K
Functions of the Lymphatic and Immune System
6.5K
The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
6.5K

