在患有Mycosis Fungoides的患者中发生囊泡突发
Feifan Chen1, Robin H Wang2, Jenna J Lullo1,2
1Department of Pathology and Laboratory Medicine, Loyola University Medical Center, Maywood, IL.
The American Journal of dermatopathology
|September 23, 2025
概括
肌性T细胞淋巴瘤的一种罕见的水泡变体Mycosis fungoides bullosa,预后不佳. 早期识别这种囊泡形状对于患者的治疗结果至关重要.
科学领域:
- 皮肤病学 皮肤病学
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 菌根性菌病是最常见的皮肤T细胞淋巴瘤.
- 菌根菌病 (Mycosis fungoides bullosa) 是一种罕见的变种,其特征是囊泡状病变.
- 据报道,目前已有不到40例mycosis fungoides bullosa的病例.
研究的目的:
- 报告一个患有晚期毛囊型真菌菌菌病的患者的真菌菌菌菌病例.
- 为了突出这一罕见亚型的临床和组织病理特征.
- 为了强调识别真菌菌病的重要性,由于其预后不佳,fungoides bullosa.
主要方法:
- 对一名66岁女性进行临床检查,皮肤干扰状况恶化.
- 皮肤病变的冲击活检.
- 组织病理学分析包括免疫型 (CD3+,CD4+,CD5-,CD7-,CD30+).
- 直接免疫光和血液培养,以排除其他原因.
主要成果:
- 患者呈现出大型的,红血状的,状的,被侵蚀的斑块,带有紧张的突起.
- 组织病理学揭示了非典型的CD3+淋巴细胞与表皮形 (CD4:CD8比为8:1),CD5/CD7的损失,以及分散的CD30+细胞.
- 在排除了感染和自身免疫性疾病后,确诊了mycosis fungoides bullosa.
结论:
- 菌根性真菌菌菌 (Mycosis fungoides bullosa) 是一种罕见的,激进的菌根性真菌菌菌变种.
- 诊断需要特征性临床病变,组织病理学,并排除其他水泡状况.
- 早期识别至关重要,因为真菌菌菌菌菌菌与预后不佳有关,在发病一年内死亡率高.
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