相关实验视频
Updated: Jan 17, 2026
11:44
Author Spotlight: Exploring the Impact of Trauma on Cellular Aging
Published on: March 22, 2024
2.9K
感染和端粒长度:一个系统的审查
Louis Tunnicliffe1, Rutendo Muzambi2, Jonathan W Bartlett1
1Faculty of Epidemiology & Population Health, London School of Hygiene & Tropical Medicine, London, United Kingdom.
PloS one
|September 23, 2025
概括
感染可能通过缩短端粒长度 (TL) 加快衰老. 虽然艾滋病毒显示了与减少TL的联系,但其他感染的证据是不一致的,需要进一步研究.
科学领域:
- 免疫学和衰老研究研究.
- 传染病和公共卫生.
背景情况:
- 感染与痴呆症等与年龄相关的疾病有关.
- 通过端粒长度 (TL) 测量的加速免疫衰老是潜在的机制.
- 特定感染与TL或端粒磨损之间的联系需要澄清.
研究的目的:
- 系统地审查有关感染与端粒长度 (TL) 或端粒衰减之间的相关性现有的文献.
- 确定研究缺口,并为未来关于这种关系的研究提供信息.
主要方法:
- 进行了全面的数据库搜索 (MEDLINE,EMBASE,科学网,Scopus,全球健康,柯克伦图书馆).
- 研究被选,数据被提取,并使用ROBINS-E.评估偏差风险.
- 由于异质性,进行了叙事综合,使用GRADE评估证据质量.
主要成果:
- 在10349项已识别的研究中,有73项符合资格标准;大多数是横截面的,发表于2000年以后.
- 人类免疫缺陷病毒 (HIV) 是研究最多的感染,79%的研究报告了与减少TL或增加端粒磨损的关联.
- 对其他感染 (例如疹病毒) 的发现是可变的,大多数研究都有高偏差风险,导致非常低的GRADE证据质量评级.
结论:
- 艾滋病毒和端粒长度/磨损之间存在潜在的关联.
- 更强大的纵向研究,标准化测量和更好的混控制是至关重要的,特别是对于非艾滋病毒感染.
- 普罗斯佩罗的注册号码是:CRD42023444854. 这是一个很好的方法.
相关概念视频
02:41Telomeres and Telomerase
26.9K
In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded...
26.9K
02:41Telomeres and Telomerase
7.0K
7.0K
02:15Replicative Cell Senescence
4.3K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
4.3K
01:29Replication in Eukaryotes
17.1K
In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
17.1K
02:31Replication in Eukaryotes
203.5K
Overview
203.5K
01:26Factors Affecting the Risk of Infection
13.3K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.3K