相关实验视频
Updated: Apr 28, 2026
08:58
Optimized Analysis of In Vivo and In Vitro Hepatic Steatosis
Published on: March 11, 2017
16.8K
剖析炎症因素,血代谢物和非酒精性脂肪肝疾病之间的因果关系:一种调解的门德尔随机化研究
Dequan Zhong1, Shizhan Deng1,2, Yonggan Dong1
1Central Laboratory, Wanbei Coal Electric Group General Hospital, Suzhou.
European journal of gastroenterology & hepatology
|September 23, 2025
概括
这项研究揭示了特定代谢物如何调解炎症和非酒精性脂肪肝疾病 (NAFLD) 之间的联系. 针对TNFRSF9等炎症因子和X-21471等代谢物,可能提供新的NAFLD预防策略.
科学领域:
- 代谢学 代谢学 代谢学
- 炎症研究 炎症研究
- 肝脏疾病 肝脏疾病
背景情况:
- 非酒精性脂肪肝 (NAFLD) 影响全球25%的成年人,涉及复杂的炎症代谢相互作用.
- 炎症因素,血代谢物和NAFLD进展之间的因果关系和机制尚未完全理解.
研究的目的:
- 用双向门德尔随机化 (MR) 方法研究炎症因素,血代谢物和NAFLD之间的因果关系.
- 检查特定代谢物在炎症-NAFLD路径中的调解作用.
主要方法:
- 双向门德尔随机化 (MR) 分析,包括全基因组关联研究的总结数据.
- 调解分析以确定将炎症信号传递到NAFLD的代谢物.
- 进行了对异质性和类型的统计测试.
主要成果:
- 确定了11个炎症因素和110个与NAFLD显著相关的血代谢物.
- 发现孕妇二硫酸盐,氨酸:氨酸比率和X-21471可以调解炎症与NAFLD的关系.
- X-21471作为瘤亡因子受体超级家族成员9 (TNFRSF9) 和CCL20.20的共享调解剂.
结论:
- 一个炎症-代谢-NAFLD轴被划定,其中代谢物传递促炎信号.
- 像X-21471和孕二硫酸盐这样的特定代谢物是NAFLD病变发生的关键媒介.
- 准TNFRSF9和X-21471为患有代谢疾病的个人提供了潜在的精确预防策略.
相关概念视频
01:22Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
271
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
271
01:24Cirrhosis II: Pathophysiology
34
Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to...
34
01:21Chronic Pancreatitis II: Pathophysiology
25
Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
25