肥胖悖论和肺癌死亡率:空气流量限制和COPD前的贡献作用
Robert P Young1, Raewyn J Scott2, Zhitian Wang2
1The University of Auckland Faculty of Medical and Health Sciences, Auckland, Auckland, New Zealand; roberty@adhb.govt.nz.
肥胖悖论,即较高的BMI与较低的肺癌死亡率相关,主要是由呼吸系统疾病解释的. 空气流量限制和COPD,在较低的BMI中普遍存在,增加肺癌死亡风险,减轻了悖论.
科学领域:
- 肺部医学 肺部医学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 这是一个很棒的节目,这是一个很棒的节目.
- 肥胖的悖论 肥胖的悖论
- (增加的BMI与减少的肺癌死亡率相关) 缺乏明确的解释.
- 潜在的因素包括性别,吸烟,糖尿病 (DM) 和研究偏见.
- 这项研究调查了呼吸道并发病症的作用.
研究的目的:
- 为了确定呼吸道并发症是否有助于肥胖悖论在肺癌死亡率.
主要方法:
- 从国家肺部查试验 (NLST) 中对18463名高风险个体的二次分析.
- 使用分层和回归模型检查了影响肺癌死亡率的因素.
- 根据肺功能和临床病史评估呼吸道并发症.
主要成果:
- 增加BMI与减少肺癌和呼吸道死亡率相关.
- 较高的BMI显示空气流量限制降低,但增加了COPD前和DM患病率.
- 空气流量限制,COPD前期和DM独立预测肺癌死亡率增加,特别是在较低的BMI. 消除这些并发症减轻了肥胖悖论.
结论:
- 高风险吸烟者肺癌死亡率中的肥胖悖论受到呼吸道并发病症的显著影响.
- 空气流量限制和COPD/DM,在较低的BMI中普遍存在,增加肺癌死亡风险,从而解释了悖论.
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