在患有食道状细胞癌的患者中,与tislelizumab相关的视网膜血管炎
Estel la Rojas-Pineda1,2, Nuria Cintas1,2, Anna Bruix1,2
1Centro de Oftalmología Barraquer, Barcelona, Spain.
Retinal cases & brief reports
|September 23, 2025
概括
与tislelizumab (一种抗PD-1抗体) 相关的视网膜血管炎在食道癌患者中观察到. 及时的皮质类固醇治疗可以控制这种情况,但复发需要重新开始治疗,这强调了需要警的眼睛监测的必要性.
科学领域:
- 眼科医生 眼科 眼科
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 免疫检查点抑制剂 (ICI),如抗PD-1抗体tislelizumab,正在彻底改变癌症治疗.
- 眼部免疫相关不良事件 (irAEs) 是已知的ICI治疗的并发症.
- 提斯莱利祖马布用于食道状细胞癌 (ESCC).
研究的目的:
- 报告患有视网膜血管炎的病例,该病例的患者接受了针对ESCC的tislelizumab治疗.
- 描述这种罕见的不良事件的临床表现,诊断结果和治疗方法.
主要方法:
- 这项研究是个案例报告.
- 进行了眼科评估,包括后视镜和光素血管造影.
- 用光学连贯断层扫描来评估视网膜变化.
主要成果:
- 一名患有ESCC的60岁男子出现了无症状的外围内出血.
- 光素血管学证实了双边视网膜血管炎,对全身皮质类固醇有反应.
- 在停止使用普得尼松后,复发发生了,并与亚管液一起复发,这种复发在重新治疗后消失.
结论:
- 与tislelizumab相关的视网膜血管炎是一个以前未报告的发现.
- 在ICI时可能会发生眼部IREs,因此需要密切的眼科监测.
- 这些事件可能无症状,晚期发展或复发,需要持续监测和管理.
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