相关实验视频

Updated: Jan 17, 2026

Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management

Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management

Published on: March 15, 2024

周围神经刺激在治疗慢性疼痛中的有效性:随机对照试验的系统审查和元分析

Laxmaiah Manchikanti¹, Massab Bashir Khaira², Amol Soin³

¹Pain Management Centers of America, Paducah, KY; Departments of Anesthesiology and Perioperative Medicine, University of Louisville, Louisville, KY; Department of Anesthesiology, School of Medicine, LSU Health Science Center, New Orleans, LA.

|September 23, 2025

概括

周围神经刺激 (PNS) 为慢性疼痛提供了一种最少的侵入性,非阿片类药物的选择. 目前的证据支持其在缓解疼痛和改善功能方面相当有效,尽管需要更多高质量的研究.

科学领域:

神经学神经学
疼痛管理疼痛管理
医疗器械医疗器械

背景情况:

周围神经刺激 (PNS) 已被用于50多年来管理慢性疼痛.
自2015年以来,FDA批准的可植入PNS系统为耐火性慢性疼痛提供了最小入侵的非阿片类药物治疗.

研究的目的:

系统地审查和分析关于PNS在慢性疼痛管理中的有效性的现有证据.
评估PNS疗法的证据质量和强度.

主要方法:

随机对照试验 (RCT) 的系统审查和元分析,遵循PRISMA指南.
使用Cochrane标准和IPM-QRB进行质量评估,通过GRADE框架对证据进行分级.
从1966年到2025年2月的文献搜索,包括手动的文献搜索.

主要成果:

确定了7个高质量和2个中等质量的RCT (科克兰标准),以及9个中等质量的试验 (IPM-QRB).
在9项研究中,7项研究的GRADE评估表明中等证据和适用性,而2项研究的证据很低.
综合分析支持III级 (公平) 证据水平,适度确定性和建议强度用于可植入PNS和临时PNS治疗.

结论:

对于慢性疼痛管理中PNS的现有证据基础是公平的 (III级),具有中等的确定性和推强度.
植入式PNS系统和临时PNS治疗证明了临床适用性.
一个显著的局限是,在这个领域缺乏高质量的研究.

关键词:

干预技术是干预技术.周围神经的刺激.周围神经病变性疼痛是什么周围神经病变 (Peripheral Neuropathy) 是一种神经病变.选择性腰部中间分支刺激慢性疼痛是一种慢性疼痛.

更多相关视频

Author Spotlight: Unveiling the Therapeutic Effects of FSN Treatment – Bridging Research and Clinical Applications in Neuropathic Pain

Author Spotlight: Unveiling the Therapeutic Effects of FSN Treatment – Bridging Research and Clinical Applications in Neuropathic Pain

Published on: June 30, 2023

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research

Published on: January 5, 2024

相关概念视频

Analgesia and Pain Management

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...