修订了中枢神经系统氧毒性暴露极限的指导方针,当使用1.3大气层的灵感PO2时
Joseph T Hoyt1, F Gregory Murphy2, Neal W Pollock3,4
1NOAA Diving Program, National Oceanographic and Atmospheric Administration, Seattle, WA, USA.
技术潜水员可以安全地在1.3 atm启发氧气下延长潜水时间. 最近的研究表明,更长的持续时间会导致脑氧毒性风险较低,更新了旧的指导方针.
科学领域:
- 高压医学的高压医学.
- 潜水生理学 潜水生理学
- 神经科学是一个神经科学.
背景情况:
- 技术和科学潜水员面临来自高压氧气暴露的脑氧毒性风险.
- 目前用于启发氧部分压力 (PO2) 的预防时间限制是在1991年建立的,基于美国海军的旧研究.
- 现代技术潜水实践,特别是长时间的减压阶段,往往超过这些既定极限,具有事的低毒性风险.
研究的目的:
- 评估实验证据,以调整技术潜水启发氧气部分压力的建议持续时间限制.
- 为了评估长时间潜水的安全性,通常使用的灵感PO2为1.3 atm.
主要方法:
- 审查最近的实验研究检查大脑氧毒性风险在启发PO2的1.3大气层.
- 分析潜水概况,包括工作和减压持续时间.
- 由国家海洋和大气管理局 (NOAA) 召开的专家委员会审查和研讨会.
主要成果:
- 启发PO2的现有持续时间限制为1.3 atm (180分单,210分/24小时) 对现代技术潜水的实验基础是有限的.
- 最近的研究表明,最长为240分钟的工作活动的潜水档案,然后在1.3 atm PO2下进行240分钟的减压,与可接受的低脑氧毒性风险有关.
- 证据特别支持1.3 atm的被启发的PO2的延长持续时间,这是恒定PO2 rebreather设备的常见设置.
结论:
- 启发PO2的1991年时间限制可能对当代技术潜水来说过于保守,特别是在1.3 atm.
- 最近的实验数据支持在1.3 atm的启发PO2下延长潜水和减压持续时间,这表明大脑氧毒性风险较低.
- 调整持续时间限制的建议已得到NOAA召开的一次研讨会的认可,该研讨会涉及技术和科学人员.
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