亚thalamic核深度大脑刺激对帕金森病的言语指标的影响
Goun Je1, Pranav Akella2, Kevin B Wilkins3
1Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, United States; Department of Neurology, Emory University School of Medicine, Atlanta, GA, United States.
Parkinsonism & related disorders
|September 23, 2025
概括
脑下核深度大脑刺激 (STN DBS) 改善了帕金森病 (PD) 患者的言语持续时间和音节率. 然而,STN DBS并没有显著改变PD中独特的语音序列效应.
科学领域:
- 神经学 神经学
- 神经外科 神经外科
- 语音科学 语言科学
背景情况:
- 帕金森病 (PD) 通常会导致语言障碍.
- 语音序列效应,PD的一个标志,是抗药的.
- 脑下核深度大脑刺激 (STN DBS) 是PD运动症状的治疗方法,但其对言语的影响尚不清楚.
研究的目的:
- 调查STN DBS对PD患者语音指标的影响.
- 具体评估STN DBS是否影响PD患者的语音序列效应.
主要方法:
- 评估了15名双边STN DBS的PD患者.
- 语音测试包括持续的发音 (SP) 和二度动力学 (DDK) 测试.
- 在OFF和ON STN DBS条件下进行了测试,测量了SP持续时间,强度,DDK速率和语音序列效应.
主要成果:
- STN DBS显著增加了SP持续时间.
- STN DBS 改善了 /pa/ 的 DDK 音节生成率.
- STN DBS并没有显著改变语音强度或语音序列效应.
结论:
- STN DBS为特定的语音参数提供好处,例如PD的持续时间和速率.
- 在PD中,STN DBS似乎没有显著地减轻语音序列效应.
- 需要对综合性语音评估进行进一步的研究,才能充分理解DBS对PD语音的影响.
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