帕纳克斯人参中的寿命和种植驱动的人参化物动态:对收获优化和药理变异的化学见解
Zheng Li1, Hang Xu1, Chong Liu1
1Institute of Special Animal and Plant Sciences of CAAS, Changchun 130112, China.
Phytomedicine : international journal of phytotherapy and phytopharmacology
|September 23, 2025
概括
这项研究揭示了花园人参 (GG) 和野生仿真人参 (WSG) 的最佳收获年龄,这些年龄是基于人参酸的概况. 罕见的金赛诺化物被确定为验证老年WSG的关键标记,有助于质量控制.
科学领域:
- 植物化学 植物化学
- 代谢学 代谢学 代谢学
- 药理学是指药理学,它是指药理学.
背景情况:
- 帕纳克斯人参被种植为花园人参 (GG) 和野生仿真人参 (WSG),但它们的差异和最佳收获时间尚不清楚.
- 缺乏确定的收获年龄标准,阻碍了这两种种植类型的质量控制.
研究的目的:
- 为了表征Panax ginseng ginsenoside资料中的年龄和种植驱动的变化.
- 为了确定GG和WSG的最佳收获窗口.
- 阐明GG和WSG之间不同药理功能的化学基础.
主要方法:
- 在不同年龄段使用高分辨率质谱学对GG和WSG进行比较代谢分析.
- 多变量统计分析 (OPLS-DA,PCA,时间序列聚类) 来分析金氏胺的动态.
- 使用标准化合物绝对量化关键的罕见人参化物.
主要成果:
- 鉴定了359种人参化物,其中54种关键化合物使老年WSG与GG区别开来.
- 对于GG的4年和WSG的7年,金色化物概况稳定.
- 发现了四种罕见的人参化物 (G-Rk3,G-Rh4,G-Rk1,G-Rg5) 作为高年龄WSG的标志物,老年WSG纤维根的水平显著更高.
结论:
- 定义的最佳收获年龄:GG的4年和WSG的7年,基于人参酸的稳定性.
- 确立了罕见的金色化物作为验证高年龄WSG的化学标记.
- 为品质控制,收获优化和Panax人参的药理标准化提供了见解.
更多相关视频
09:16Author Spotlight: Optimization of Processing Technology for Tiebangchui with Zanba Based on CRITIC Combined with Box-Behnken Response Surface Method
Published on: May 12, 2023
1.5K
13:35Structural Biology and Analytical Chemistry Approaches for Characterizing C-Glycoside Metabolic Enzymes in Human Gut Microbiota
Published on: May 23, 2025
927
相关概念视频
01:27Pharmacodynamics in Geriatric Patients: Effects of Age
188
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
188
01:22Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
229
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
229
01:18Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
197
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
197
01:00Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution
232
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
232
01:24Pharmacokinetics in Pediatric Patients: Drug Metabolism
195
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
195
01:12Analysis of Population Pharmacokinetic Data
682
Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
682