作为发育协调障碍的预测因素,对于妊娠年龄来说小:探索日本出生队列联盟的早期风险
Hiroyoshi Iwata1, Maki Tojo1, Kenji J Tsuchiya2
1Hokkaido University Center for Environmental and Health Sciences, North-12, West-7, Kita-ku, Sapporo, Hokkaido, Japan.
Brain & development
|September 23, 2025
概括
对于妊娠年龄来说小 (SGA) 是发育协调障碍 (DCD) 的潜在危险因素. 这项研究整合了来自日本三个出生队伍的数据,以调查儿科发育中的这种联系.
科学领域:
- 儿科发展 儿科发展
- 发育儿科 发育儿科
- 儿童健康研究 儿童健康研究
背景情况:
- 对于妊娠年龄来说小 (SGA) 和发育协调障碍 (DCD) 是儿科发育中的重大问题.
- 了解SGA和DCD之间的联系对于早期干预和支持至关重要.
- 目前关于SGA-DCD关系的研究仅限于单一队列研究.
研究的目的:
- 整合来自日本出生队列联盟 (JBiCC) 内的多个队列的DCD发现.
- 通过使用更大,综合数据集,调查SGA和DCD之间的关联.
主要方法:
- 利用了JBiCC中的三个潜在出生队列的数据:北海道研究,HBC研究和TMM BirThree队列研究.
- 在使用DCDQ-J或ASQ-3的4-7岁儿童中评估DCD.
- 在每个队列中进行了后勤回归,随后进行了元分析和个人患者数据 (IPD) 的元分析.
主要成果:
- 包括三个队伍中的14233名儿童.
- 两个队列的元合成显示出显著的关联 (β = -2.63,95% CI [-5.22, -0.03]).
- IPD元分析证实了这一关联 (β = -2.76,95% CI [-5.38, -0.15]).
结论:
- 对于妊娠年龄来说小 (SGA) 被认为是发展协调障碍 (DCD) 的潜在危险因素.
- 这些发现支持需要提高SGA婴儿的DDC意识和查.
- 这一综合分析提供了强有力的证据,加强了SGA和DCD之间的关联.
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