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Updated: Jan 17, 2026

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弱监督的-TCR结合预测可以促进新抗原的识别.

Yuli Gao1, Yicheng Gao1, Siqi Wu1

  • 1Department of Hematology, Tongji Hospital, Frontier Science Center for Stem Cell Research, Bioinformatics Department, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China; Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, Frontier Science Center for Stem Cell Research, Bioinformatics Department, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.

Cell systems
|September 23, 2025
PubMed
概括

识别用于癌症免疫治疗的T细胞新抗原是复杂的. 新的框架TCRBagger通过建模患者特定的T细胞受体配置文件来增强个性化的新抗原预测,以改善免疫性评估.

关键词:
新抗原鉴定新抗原鉴定样本特定的TCR配置文件.瘤免疫疗法 免疫疗法缺乏监督的学习学习.

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Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
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