在抗血管内皮生长因子注射后,短暂的视力和眼内压力变化
Khaldon Abbas1, Amy Basilious1, Julie Duncan2
1Ivey Eye Institute, St. Joseph's Health Care Centre, London, ON, Canada; Department of Ophthalmology and Visual Sciences, University of Western Ontario, London, ON, Canada.
Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
|September 23, 2025
概括
在注射抗血管内皮生长因子 (抗VEGF) 后,眼内压力 (IOP) 和视力敏度 (VA) 暂时恶化,但通常在30分钟内恢复. 意识到这些短暂的变化是管理潜在并发症的关键.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗血管内皮生长因子 (抗VEGF) 注射是各种视网膜疾病的标准治疗方法.
- 注射后经常观察到眼内压力 (IOP) 和视敏度 (VA) 的暂时变化.
研究的目的:
- 评估抗VEGF注射对IOP和VA的直接和短期影响.
- 为了确定可能影响IOP和VA在静脉内注射后恢复的因素.
主要方法:
- 一项前性观察性研究,包括接受抗VEGF药物的86名患者 (100只眼睛).
- 内压和VA在注射后的多个时间点 (基线,1,10,20,30分钟) 测量.
- 统计分析包括斯皮尔曼的相关性和顺序逻辑回归.
主要成果:
- 注射后1分钟发生了显著的,短暂的内血压增加和VA恶化 (p < 0.001).
- 在注射后30分钟内,VA和内压在很大程度上恢复到基线水平,89%的眼睛达到基线VA.
- 在注射后1分钟 (p=0.014) 观察到VA和IOP之间的显著相关性.
结论:
- 抗VEGF注射通常会导致IOP暂时升高和VA减少,随后恢复.
- 关于这些短暂的注射后波动的患者教育对于管理潜在的并发症很重要.
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