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对原始和碳化Linderae Radix的成分和抗性结肠炎作用的比较研究

Xunjie Zheng¹, Ke Li¹, Jiangning Hu²

¹School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310053, China.

Journal of ethnopharmacology

|September 23, 2025

概括

碳化改变了Linderae Radix (LR) 的化学成分,影响了其用于性结肠炎 (UC) 的使用. 未加工的LR有助于粘膜再生,而碳化LR (CLR) 则加强粘膜屏障并减少炎症.

科学领域:

药理学和中国传统医学
胃肠病学和炎症性肠病研究
化学分析和网络药理学

背景情况:

林德拉根 (Linderae Radix,LR) 是一种用于治疗性结肠炎 (UC) 的传统中医药.
碳化Linderae Radix (CLR) 是通过炸从LR衍生出来的.
碳化对LR化学特征和UC治疗功效的影响尚不清楚.

研究的目的:

为了比较LR和CLR的化学成分.
评估和对比LR和CLR在硫酸 (DSS) 诱导的UC小鼠模型中的治疗效果.
在UC治疗中阐明LR和CLR的潜在作用机制.

主要方法:

超高性能液态色谱与飞行时间质谱学 (UPLC-Triple-TOF/MS) 结合,用于化学分析.
一个2.5%的DSS诱导的UC小鼠模型来评估治疗疗效.
组织病理学分析,免疫组织化学,免疫光学和网络药理学与分子对接来研究机制.

主要成果:

碳化显著改变了LR的化学成分,导致一些化合物的损失和新化合物的出现.
在UC模型中,LR和CLR都表现出治疗效益,包括改善表皮质完整性和增殖.
LR在减少组织学损伤和保存密码结构方面表现更好,而CLR在通过MUC2上调恢复粘液屏障方面表现出色.
网络药理学表明了不同的机制性途径:LR针对再生途径 (Wnt,Notch,JAK-STAT),而CLR专注于炎症和亡途径 (MAPK,PI3K-Akt,IL-17).

结论:

碳化显著改变了Linderae Radix.的化学成分和治疗焦点.
主要支持粘膜再生和肠道干细胞活动.
在性结肠炎的背景下,CLR增强了粘液屏障功能,并调节了炎症反应.

关键词:

真正的地区毒品.肠道屏障肠道屏障肠道屏障这就是LC-MS.林德雷 (Linderae Radix) 是一个有根的植物.处理处理处理性结肠炎是一种

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