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Updated: Jan 17, 2026

DNA Vector-based RNA Interference to Study Gene Function in Cancer
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DNA Vector-based RNA Interference to Study Gene Function in Cancer

Published on: June 4, 2012

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LTO1和YAE1通过瘤细胞的无意义介导RNA衰变来调节MHC-I表达

Zhengning Yang1, Zhongxuan Meng1, Shangyuan Liu1

  • 1GMU-GIBH Joint School of Life Sciences, The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, Guangdong, China.

Journal for immunotherapy of cancer
|September 23, 2025
PubMed
概括

LTO1/YAE1复合体通过无意中介的mRNA衰变 (NMD) 调节癌细胞抗原呈现. 抑制这种复合物可以增强MHC-I的表达,促进T细胞的激活和免疫疗法的有效性.

关键词:
一个T细胞细胞.免疫检查点抑制剂免疫检查点抑制剂主体组织相容性复杂 - MHC.

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