一个开源骨年龄AI的特定人口校准和验证
Sebastian Rassmann1,2, Luka Abashishvili3, Elene Melikidze3
1Institute for Genomic Statistics and Bioinformatics, University Hospital Bonn, Bonn, Germany.
Scientific reports
|September 23, 2025
概括
人工智能 (AI) 对骨龄 (BA) 评估进行了适应格鲁吉亚儿童. 校准的AI模型Deeplasia-GE显著提高了准确性,为此群体的儿科生长监测提供了可靠的工具.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 医学成像分析分析 医学成像分析
- 医疗保健中的人工智能
背景情况:
- 准确的骨龄 (BA) 评估对于监测儿科生长和指导激素治疗等治疗至关重要.
- 现有的人工智能 (AI) 模型用于BA评估,由于对有限的,非多样化的数据集进行培训,往往缺乏通用性.
- 骨生长的特定人群变化需要定制的AI解决方案来准确评估骨成熟度.
研究的目的:
- 适应和验证一个开源的人工智能工具 (Deeplasia) 用于格鲁吉亚儿科人口的骨龄评估.
- 为了解决有关现有AI BA模型对代表性不足的祖先的适用性的担忧.
- 提高格鲁吉亚儿童自动化BA评估的准确性和可靠性.
主要方法:
- 从格鲁吉亚人口中回顾收集了381张儿科手部X射线.
- 由七位当地儿科专家建立手动骨年龄参考评级.
- 使用121张图像对Deeplasia AI模型进行性别特定的线性校准,创建Deeplasia-GE.
- 在一组260张图像的测试中对模型性能进行评估.
主要成果:
- 默认的Deeplasia模型显示平均绝对差异 (MAD) 为6.57个月,在校准后 (Deeplasia-GE) 改善到5.69个月.
- 默认模型对BA的初始高估 (女性SMD为+2.85个月,男性SMD为+5.35个月) 被Deeplasia-GE显著降低 (-女性0.03个月,男性SMD为+0.58个月).
- 迪普拉西亚-GE表现出比个人人类评分器更小的误差,并保持了高的测试-重新测试可靠性.
结论:
- 校准的AI模型Deeplasia-GE提供了一种可靠和准确的方法来评估格鲁吉亚儿童的骨年龄.
- 这项研究强调了针对人工智能驱动的医疗诊断工具的人口特定校准的重要性.
- 在格鲁吉亚医疗保健系统内,Deeplasia-GE为儿科生长监测和治疗指导提供了宝贵的进步.
相关概念视频
01:18Classification of Bones
9.4K
The bones of the human skeletal system are of varied shapes, sizes, and functions. They can be classified based on their shape and function into four major classes: long bones, short bones, flat bones, and irregular bones. Some classifications include a fifth type, the sesamoid bones, as a separate class, whereas others categorize them under short bones.
Long and Short Bones
The appendicular skeleton, particularly the upper and lower limbs, is primarily made of long and short bones. The...
Long and Short Bones
The appendicular skeleton, particularly the upper and lower limbs, is primarily made of long and short bones. The...
9.4K
01:09Changes in the Appendicular Skeleton with Age
3.3K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
3.3K
01:40Bone Remodeling
40.2K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.2K