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预防性表面活性剂治疗在较少侵入性表面活性剂输送时代
Dinushan C Kaluarachchi1, Anup Katheria2, Patrick J Peebles3
1Department of Pediatrics, University of Wisconsin - Madison, Madison, WI, USA. kaluarachchi@pediatrics.wisc.edu.
概括
预防性表面活性剂治疗早产婴儿不建议通过喉沉积或短暂的输管. 然而,薄导管输送显示了预防呼吸困扰综合征 (RDS) 的前途.
科学领域:
- 新生儿医学 新生儿医学
- 肺部医学 肺部医学
- 儿科重症监护 儿科重症监护
背景情况:
- 肺表面活性剂对于治疗早产婴儿的呼吸应急综合征 (RDS) 是至关重要的.
- 较少侵入性的表面活性剂输送方法正在出现,这促使人们重新评估预防性使用.
- 尽量减少机械通风是新生儿呼吸护理的一个关键目标.
研究的目的:
- 审查目前关于用于RDS的预防性应用较少侵入性表面活性剂治疗的证据.
- 评估不同预防性表面活性剂施用技术的安全性和有效性.
- 确定预防性表面活性剂管理的未来研究领域.
主要方法:
- 对有关预防性表面活性剂的现有文献进行系统审查.
- 对各种输送方法的证据分析,包括喉沉积,简短的输内管道,上气道,气溶液和薄导管.
- 考虑正在进行的随机临床试验.
主要成果:
- 目前不建议通过喉沉积或短暂输管进行预防性表面活性剂的使用.
- 通过supraglottic气道或气溶液输送表面活性剂尚未充分研究预防.
- 最近的数据表明,通过薄导管进行预防性表面活性剂的使用是安全和有效的.
结论:
- 薄导管预防性表面活性剂的使用是预防早产婴儿RDS的一个有希望的策略.
- 进一步的随机临床试验至关重要,以确认薄导管输送的有效性.
- 未来的研究应该探索通过supraglottic气道装置和气溶的预防性表面活性剂的管理.
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