由大脑状态依赖的皮层-皮层配对-关联刺激诱导的半球间运动皮层连接的可塑性
Maria Ermolova1,2, Gábor Kozák1,2, Paolo Belardinelli1,2,3
1Department of Neurology and Stroke, University of Tübingen, Tübingen, Germany.
Scientific reports
|September 23, 2025
概括
该研究发现,虽然配对的关联性刺激可以加强半球间运动皮质连接 (SIHI),但大脑节律的时间 (μ-节律阶段) 没有改变这种长期效应. 这表明不同大脑路径具有不同的可塑性机制.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 大脑的可塑性 大脑的可塑性
背景情况:
- 初级运动皮层 (M1) 之间的跨腔通路对于手动运动协调至关重要.
- 短间隔半球间抑制 (SIHI) 评估M1-M1有效连接使用跨磁刺激 (TMS).
- 感觉运动μ-节律阶段影响皮质脊髓刺激性和可塑性.
研究的目的:
- 研究两种M1中持续的μ-节律阶段对SIHI长期变化的影响.
- 为了确定M1-M1连接的ccPAS诱导的可塑性是否相位依赖.
主要方法:
- 健康的受试者接受了皮层-皮层配对关联刺激 (ccPAS),针对双边M1s.
- 在四个μ-节律阶段条件中应用ccPAS:低谷-低谷,低谷-正峰,正峰-低谷和随机阶段.
- 测量SIHI以评估有效的M1-M1连接在刺激前后.
主要成果:
- ccPAS诱导了SIHI的长期加强,表明增强了M1-M1连接.
- 在不同μ-节律相条件下,SIHI可塑性没有显著差异.
- 这与之前关于皮质脊髓刺激性的发现形成鲜明对比,这表明塑性调节的不同.
结论:
- 用SIHI测量的M1-M1连接的可塑性在ccPAS期间不受μ-节律相调节.
- 这些发现突出了控制皮质脊髓和半球间M1可塑性的独特机制.
- ccPAS诱导的M1-M1连接的加强为调节半球间平衡提供了潜在的治疗应用.
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