新的1,2,3-triazole-linked (±) -agrimonolide衍生物作为抗性结肠炎药物,可以抑制JAK1/STAT3通路

Xiao Zhang1,2, Ming-Qian Ju1,2, Heng-Li Yang1,2

  • 1Yunnan Key Laboratory of Dai and Yi Medicines, Yunnan University of Chinese Medicine, Kunming, 650500, China.

Molecular diversity
|September 23, 2025
PubMed
概括

新的1,2,3-triazole衍生物显示出对性结肠炎 (UC) 有强大的抗炎作用. 化合物6d通过抑制炎症媒介和JAK1/STAT3通路来缓解UC,提供了一个有前途的治疗途径.

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