用真空压缩成型的聚乙醇微针,用于持续三天的帕洛诺塞龙化通过皮肤递送
Meheli Ghosh1, Sharvari M Kshirsagar1, Thomas Kipping2
1Center for Drug Delivery Research, Department of Pharmaceutical Sciences, College of Pharmacy, Mercer University, 3001 Mercer University Drive, Atlanta, GA, 30341, USA.
Drug delivery and translational research
|September 23, 2025
概括
真空压缩成型 (VCM) 提供了一种新的,无溶剂的方法,用于制造palonosetron化 (PAL HCl) 微针. 这种方法使得持续的,三天的透皮输送能够改善化疗诱导的恶心和吐管理.
科学领域:
- 制药科学 制药科学
- 生物材料工程 生物材料工程
- 药物输送系统 药物输送系统
背景情况:
- 帕洛诺塞龙化物 (PAL HCl) 对于治疗化疗引起的恶心和吐 (CINV) 非常重要.
- 对于PAL HCl,传统的药物输送方法面临着诸如延长干燥时间和溶剂残留等局限性.
- 微针 (MN) 技术为无痛,符合药物管理提供了一个有希望的替代方案.
研究的目的:
- 开发和评估一个可扩展的,无溶剂真空压缩成型 (VCM) 方法,用于制造PAL HCl装载聚乙醇 (PVA) 微针.
- 为了实现PAL HCl的持续,三天的体外透皮药物输送,以加强CINV管理.
- 为了优化PVA配方的机械完整性,皮肤透和药物释放特性.
主要方法:
- 对十种PVA等级进行选,以确定最佳的微针制造特性.
- 使用VCM技术制造PAL HCl装载的PVA微针.
- 使用SEM进行几何特征,FTIR和DSC用于物理化学性质,以及体外释放和透研究.
主要成果:
- 三种PVA配方 (M1,M4,M5) 呈现出适当的机械强度和皮肤透 (约. 200微米) 的时间.
- 物理化学分析证实了PAL HCl在PVA矩阵中的无形状态,没有化学相互作用.
- 试验室研究表明,双相释放的样本持续发射长达72小时;配方M1实现了100%的释放和优越的皮肤透 (257.56μg/cm2).
结论:
- VCM是一个可扩展和可调节的平台,用于生产PAL HCl装载PVA微针.
- 开发的微针可持续通过皮肤递送药物,显示出CINV管理的巨大潜力.
- 与传统方法相比,优化的配方提供了更好的药物释放和透.
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