生物流体外体:转化医学中的承诺,挑战和未来方向
Fatemeh Soltanmohammadi1,2, Maryam Maghsoodi2, Effat Alizadeh3
1Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Journal of translational medicine
|September 23, 2025
概括
外体,细胞中的微小囊泡,携带用于通信和疾病洞察的分子. 本综述探讨了它们在个性化医学的诊断和治疗方面的潜力.
科学领域:
- 生物化学 生物化学
- 细胞生物学 细胞生物学
- 纳米技术纳米技术
背景情况:
- 外体是细胞外囊泡 (EVs),对于细胞间通信至关重要.
- 它们运输蛋白质,核酸和脂质,影响健康和疾病.
- 外基因组在免疫反应和疾病进展中起作用.
研究的目的:
- 审查生物流体衍生外体,涵盖生物发生,组成和隔离.
- 突出外体细胞在诊断,治疗和个性化医学中的应用.
- 讨论临床试验和异位体翻译方面的挑战.
主要方法:
- 关于外体细胞研究的综合文献综述.
- 对外体生物发生的分析,分子载荷和隔离方法.
- 检查诊断和治疗应用以及临床试验.
主要成果:
- 外体是具有诊断和治疗潜力的多功能纳米载体.
- 来自生物流体的外体作为各种疾病的非侵入性生物标志物.
- 外基因组在药物输送,再生医学和免疫疗法方面表现有前途.
结论:
- 来自生物流体的外体在现代医学中具有革命性的潜力.
- 临床翻译需要进一步的研究和技术进步.
- 外体是开发精准医学策略的关键.
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