对临床使用的快速蒙特卡洛剂量引擎进行比较研究,用于质子疗法
Sherif M Gadoue1, Narayan Sahoo1
1Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Journal of applied clinical medical physics
|September 24, 2025
概括
质子治疗的快速蒙特卡洛 (MC) 代码在患者剂量计算中显示出高准确性. 单个和双个高斯模型都实现了极好的马通率,验证了它们的临床用途.
科学领域:
- 医学物理 医学物理
- 计算物理 计算物理
- 放射治疗 物理 物理
背景情况:
- 快速蒙特卡洛 (MC) 代码对于模拟质子运输和计算质子疗法患者剂量至关重要.
- 目前的比较通常涉及完整的MC代码,需要直接评估快速的MC代码.
研究的目的:
- 为了比较来自不同快速MC代码的剂量计算的马传递率 (GPR).
- 在质子疗法中评估各种快速MC代码的准确性和建模能力.
主要方法:
- 为临床质子束线委托了两个基于GPU和一个基于CPU的MC代码.
- 模拟的GPU代码采用单个2D高斯代码和CPU代码采用双个2D高斯代码.
- 在7个治疗地点使用3D马分析对待治疗计划系统 (TPS) 评估了70个患者计划.
主要成果:
- 与TPS相比,所有快速MC代码都显示出极好的剂量计算精度.
- 在所有治疗部位的马传导率 (GPRs) 从96.29%到99.99%不等.
- 双高斯模型通常比单个高斯模型产生更高的GPR,在前列腺病例中只有少数例外.
结论:
- 所有评估的快速MC代码都实现了临床质子疗法可接受的3DGPR.
- 单体和双体二维高斯模型都足够有效,可以在质子疗法中准确计算剂量.
- 这些发现支持快速MC代码用于患者剂量验证的临床实用性.
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