多方面饮食暴露和心房动:双向因果证据来自双样本的门德尔随机化研究
1Department of Cardiology, The First People's Hospital of Xiaoshan District, Hangzhou, Zhejiang Province, China.
Medicine
|September 24, 2025
概括
较高的猪肉和盐摄入量可能会增加心房的风险. 相反,食用更多的干果可能有助于预防心房动. 需要进一步的研究来证实这些饮食联系.
科学领域:
- 心血管流行病学心血管流行病学
- 营养科学 营养科学
- 遗传流行病学遗传流行病学
背景情况:
- 观察性研究表明饮食因素影响心房动 (AF) 风险,但因果关系尚不清楚.
- 现有的研究缺乏关于饮食和AF之间的关系方向性的确证据.
- 门德尔的随机化 (MR) 提供了一种方法来研究使用遗传变异的因果关系.
研究的目的:
- 探索特定饮食摄入量与心房动 (AF) 风险之间的潜在因果关系.
- 用两样 MR 方法确定饮食因素和 AF 之间的关联的方向性.
- 为了确定可能增加或减少AF风险的饮食成分.
主要方法:
- 采用了两个样本的门德尔随机化 (MR) 设计.
- 利用了来自英国生物库的饮食摄入量全基因组关联研究 (GWAS) 数据.
- 从FinnGen联盟中提取了对心房的GWAS数据.
- 使用反变量加权 (IVW) 方法进行初级分析.
- 进行敏感性和复制性分析,以确保结果的稳定性.
主要成果:
- 基因预测较高的猪肉消费因果相关,与增高的AF风险有关 (OR:7.185,P=0.002).
- 增加添加到食品中的盐量显示与较高的AF风险存在因果关系 (OR:1.465,P=0.009).
- 干果的摄入量较高因果相关性与AF风险降低有关 (OR:0.501,P=0.012).
- 对于其他研究的饮食因素,没有发现显著的因果关系.
- 反向MR分析表明没有证据表明AF影响饮食因素.
结论:
- 较高的猪肉和添加盐的摄入量可能会因果性地增加患心房的风险.
- 增加干果的消费可能会对AF产生保护作用.
- 这些发现突出了AF预防的潜在饮食目标,需要进一步调查.
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