与免疫相关的不良事件管理的现状以及瘤学家教育的实际需求
Binhe Tian1, Yuanmei Yang1, Shuman Kuang2
1Department of Pulmonary and Critical Care Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
Cancer biology & medicine
|September 24, 2025
概括
免疫检查点抑制剂改善了癌症治疗,但增加了与免疫相关的不良事件 (irAEs). 本次审查强调了对这些复杂的副作用需要更好的管理策略,以确保持续使用免疫疗法.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 临床医学 临床医学
背景情况:
- 免疫检查点抑制剂 (ICI) 已经彻底改变了先进的癌症治疗.
- 广泛使用ICI导致免疫相关不良事件 (irAEs) 显著增加.
- irAEs带来了各种各样的临床挑战,包括不同发病,广泛的毒性和复杂的管理,影响治疗坚持和生活质量.
研究的目的:
- 系统地审查irAEs的流行病学,临床过程和当前管理.
- 确定现有指导方针和临床实践对irAE管理的局限性.
- 为标准化和长期管理IRAE提出改进建议.
主要方法:
- 对irAEs的文献进行系统审查.
- 对流行病学特征,临床进展和管理策略的分析.
- 评估当前的指导方针和临床实践挑战.
主要成果:
- 现有的指导方针主要针对急性irrAEs,缺乏针对慢性,延迟或多系统事件的结构化方法.
- 临床管理受到分散的护理,瘤学家培训不足以及缺乏多学科合作的阻碍.
- 不有效的irAE管理会影响免疫治疗的长期疗效.
结论:
- 需要加强策略来管理IRE的频谱.
- 将irAE管理纳入瘤学培训是必不可少的.
- 建立全面的跨学科框架对于标准化的长期免疫疗法使用至关重要.
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