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下皮层激活和功能连接的改变是ASD中被动听觉空间注意力的特征

Sergio Osorio^1,2, Jasmine Tan^1,2, Grace Levine^1,2

¹Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, Massachusetts, USA.

Autism research : official journal of the International Society for Autism Research

|September 24, 2025

概括

患有自闭症谱系障碍 (ASD) 的儿童在他们的大脑如何处理声音位置方面表现出差异. 这项研究揭示了与ASD中的听觉空间注意力相关的大脑活动和连接性的改变.

科学领域:

神经科学是一个神经科学.
发展心理学发展心理学
听觉神经科学听觉神经科学

背景情况:

自闭症谱系障碍 (ASD) 涉及到社会和沟通方面的挑战.
对于社交互动至关重要的听觉空间注意力在ASD中没有得到充分研究.
之前的研究表明,在ASD中异常的听觉处理.

研究的目的:

研究ASD儿童被动听觉空间注意力的神经差异.
比较ASD和典型发育 (TD) 儿童之间的大脑活动和功能连接.
检查神经发现和行为结果之间的关系.

主要方法:

在ASD和TD对照的儿童中使用源局部化磁脑电图 (MEG).
呈现了被动的,非社会性的听觉刺激,与"停留"和"跳跃"位置的变化.
应用线性混合效应建模和功能连接分析.

主要成果:

在"跳跃"试验中,ASD组在听觉皮层表现出较低的皮质激活.
自闭症组在听觉和前额/副额区域之间显示出更高的α频段功能连接.
连接模式与听觉处理得分和ASD症状严重程度相关.

结论:

在患有自闭症的儿童中,听觉空间注意力的神经机制不同.
结果支持在ASD中改变了声音方向处理,即使是被动的.
这些差异可能会导致ASD的社会沟通挑战.

关键词:

自闭症自闭症是什么功能连接性的功能连接性磁脑脑摄影 (MEG) 是一种磁脑脑摄影技术.感官处理感官处理声音本地化声音本地化

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