胃汁微RNA作为功能性消化不良的生物标志物:一项观察性病例控制研究
Radu A Farcas1, Teodora Surdea-Blaga1, Ştefan Popa1
12nd Department of Internal Medicine, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Frontiers in medicine
|September 24, 2025
概括
胃汁微RNAs (miRNAs) 在功能性消化不良 (FD) 中表现出改变的特征,具有区分亚型的特定模式. 这些发现表明miRNAs可能是用于FD诊断和风险分层的新生物标志物.
科学领域:
- 胃肠病学 胃肠病学
- 分子生物学分子生物学
- 生物标志物发现发现
背景情况:
- 微RNAs (miRNAs) 是关键的基因调节剂,具有作为诊断生物标记物的潜力.
- 功能性消化不良 (FD) 由于复杂的病理生理学而带来诊断挑战.
- miRNAs可能为FD诊断和风险分层提供新的见解.
研究的目的:
- 在功能性消化不良 (FD) 患者中调查胃汁miRNA配置文件.
- 为了区分FD亚型 (EPS和PDS) 和健康对照之间的miRNA表达.
- 探索miRNA水平和FD症状严重程度之间的相关性.
主要方法:
- 观察性病例控制研究,包括28名FD患者和22名健康对照.
- 通过胃镜收集胃汁.
- 定量实时PCR测量miR-21-5p,miR-155-5p和miR-203a水平. 这是一个非常好的方法.
主要成果:
- 与对照组相比,FD患者的miR-21-5p显著升高.
- 在FD亚型之间观察到不同的miRNA配置文件:PDS与EPS相比显示出更高的miR-21/miR-155和更低的miR-203.
- miRNA水平与特定症状相关,这表明有病理生理学联系.
结论:
- 胃汁 miRNA 配置的变化,特别是 miR-21 的上调,与 FD 相关.
- 胃汁miRNA可以作为FD的最小侵入性生物标志物,有助于亚型分化.
- 需要进一步的研究来确认诊断效用和在FD病变发生中的作用.
相关概念视频
01:23Gastritis III: Clinical Manifestations and Management
1.2K
The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
1.2K
01:50What is Monogastric Digestion?
75.0K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
75.0K
01:28Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
541
Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
541
01:17Gastritis-II: Pathophysiology
1.2K
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
1.2K
01:26Gastric Phase of Digestion
3.1K
The gastric phase of digestion begins as soon as food enters the stomach. The incoming food bolus triggers neural and hormonal mechanisms, which last approximately 3 to 4 hours. During this phase, the stomach undergoes significant changes to prepare the food for further digestion and absorption.
When food enters the stomach, it stretches the stomach walls and activates stretch receptors. This triggers local reflexes of the enteric nervous system, mediated through the myenteric plexus. These...
When food enters the stomach, it stretches the stomach walls and activates stretch receptors. This triggers local reflexes of the enteric nervous system, mediated through the myenteric plexus. These...
3.1K
01:24Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors
1.1K
Peptic ulcer disease, commonly called PUD, represents a multifaceted condition characterized by disruptions in the lining of the gastrointestinal (GI) tract. Central to the protection of the gastrointestinal lining is the mucosal-bicarbonate barrier. This physiological defense mechanism is a formidable shield against the corrosive effects of gastric acid and pepsin secretion in the stomach. Its role is pivotal in maintaining the structural integrity of the stomach's inner lining.
1.1K