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德克萨米他视膜内植入物的眼内位置与注射后眼内压力升高之间的关系

Dingxi Liu¹, Yue Chen¹, Xiaonan Fu¹

¹Department of Ophthalmology, The Third People's Hospital of Dalian, Dalian, China.

Frontiers in medicine

|September 24, 2025

概括

德甲视内植入物 (DEX-I) 的P1植入位置与眼内压力 (IOP) 的升高有关,特别是在注射后的早期. 谨慎的放置可以帮助管理注射后的IOP风险.

科学领域:

眼科医生眼科眼科
视网膜疾病视网膜疾病
药理学药理学是指药理学的学科.

背景情况:

眼内压力 (IOP) 升高是静脉内皮质类固醇植入物的潜在并发症.
德克萨米他肠内植入物 (DEX-I) 广泛用于各种视网膜疾病.
了解影响注射后内压升高的因素对于患者管理至关重要.

研究的目的:

为了研究德克萨米他视膜内植入物 (DEX-I) 的植入位置与注射后眼内压力 (IOP) 升高之间的关系.
为了确定特定的植入物位置,与IOP尖峰的风险增加有关.

主要方法:

对324名接受DEX-I治疗的患者的332只眼睛进行了回顾性研究.
将DEX-I植入位置分类为P1 (近眼体),P2 (赤道前) 和P3 (赤道后).
植入位置和IOP升高之间的相关性分析 (定义为>25 mmHg或从基线增加10 mmHg).

主要成果:

68只眼睛 (20.48%) 经历了注射后的内压升高.
与P2和P3相比,P1植入位置显示IOP升高的发生率明显高 (p < 0.001).
P1植入与早期IOP升高 (15天内) 有很强的相关性 (r = 0.761,p < 0.001).

结论:

P1植入位置是注射后IOP升高的重要风险因素.
在DEX-I注射后IOP早期升高与P1位置特别相关.
最佳的植入物放置可能有助于减轻DEX-I诱导的内压升高的风险.

关键词:

在DEX-i中使用DEX-i.IOPOP IOPOP IOPOP IOP IOP IOP IOP IOP IOP IOP IOP IOP IOP IOP IOP IOP IOP IOP IOP IOP IOP IOP IOP 德克萨米他内内植入物植入物植入物植入位置的植入位置.眼内压力升高眼内压力升高

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