氧化应激在调节高血压控制级联中死亡风险中的作用
Weihao Liu1, Chunyang Hou1, Hongjie Wang1
1Department of Urology, The First Hospital of Jilin University, Changchun, Jilin, China.
Frontiers in cardiovascular medicine
|September 24, 2025
概括
较高的氧化平衡评分 (OBS) 与高血压患者的死亡率降低有关,特别是那些血压受控的人. 这种益处部分归因于减少炎症和更好的器官功能.
科学领域:
- 心血管研究研究心血管研究
- 营养流行病学 营养流行病学
- 公共卫生 公共卫生
背景情况:
- 氧化应激在高血压中起着至关重要的作用,但其对死亡率的影响尚未完全理解.
- 氧化平衡评分 (OBS) 量化了与氧化压力相关的饮食和生活方式因素.
- 调查OBS-高血压-死亡率关系对于公共卫生战略至关重要.
研究的目的:
- 检查氧化平衡评分 (OBS) 与美国高血压成年人全因和心血管死亡率之间的关联.
- 评估高血压控制状态如何改变OBS与死亡率的关系.
- 研究低级系统性炎症和多器官功能中介作用.
主要方法:
- 1999-2018年国家健康和营养检查调查 (NHANES) 数据的分析.
- 包括患有高血压的美国成年人,以及来自国家死亡指数 (NDI) 的死亡率数据.
- 统计方法包括卡普兰-梅尔分析,考克斯模型,受限立方线,子组分析和调解分析,以评估OBS,炎症和器官功能.
主要成果:
- 较高的OBS四分位数与明显较低的全因和心血管死亡率有关.
- 在控制高血压的人群中,OBS对死亡率的保护作用比控制不了高血压的人群更为明显.
- 调解分析表明,低级系统性炎症和多器官功能部分解释了OBS与死亡率的关联.
结论:
- 较高的氧化平衡得分与高血压人群的死亡率降低有关.
- 高血压控制状态显著影响OBS在减轻死亡风险方面的有效性.
- 这些发现强调了生活方式和营养因素在管理高血压相关死亡率方面的重要性,其中部分介导由炎症和器官功能标志物.
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