验证了新型的酸性食道炎症状问卷
Eilish McCann1, Mirna Chehade2, Jonathan M Spergel3
1Regeneron Pharmaceuticals Inc, Tarrytown, NY.
The journal of allergy and clinical immunology. Global
|September 24, 2025
概括
乙性食管炎症状问卷 (EoE-SQ) 可靠地测量了EoE患者除了食管障碍之外的症状. 确定了临床上有意义的得分变化,支持其在临床试验和实践中的使用.
科学领域:
- 胃肠病学 胃肠病学
- 临床试验 临床试验
- 患者报告的结果
背景情况:
- 性食道炎 (EOE) 显著影响患者的生活质量.
- 现有的措施往往仅集中在食障碍上,忽视其他EoE症状.
- 需要一个经过验证的工具来捕捉EoE症状的全谱.
研究的目的:
- 引入和验证新型的异性食道炎症状问卷 (EoE-SQ).
- 评估EoE-SQ在患有EoE的成人和青少年中的心理测量特性和临床意义.
主要方法:
- 在第三阶段临床试验 (NCT03633617) 中,EoE-SQ给了239名患者.
- 评估了包括可靠性,构造有效性和响应能力在内的心理测量属性.
- 使用患者的全球评估确定了临床上有意义的得分变化.
主要成果:
- 该EoE-SQ表现出良好的内部一致性,测试-重新测试可靠性和构造有效性.
- 评分与其他EoE特定措施有中度至强度的相关性.
- 问卷显示出良好的响应,在患者的统计学上有显著的改善,总体评估有所改善.
结论:
- 经过EoE-SQ是评估经过EoE症状之外的可靠和有效的测量方法.
- 它表现出对治疗和临床变化的良好反应.
- 可以将EoE-SQ与其他PRO一起使用,以全面评估成人和青少年的EoE症状.
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