自然化合物的纳米晶体药物输送系统:进展,挑战和未来的机遇
Manting Ji1, Li Long1, Sijia Xiong1
1Department of Pharmacy, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330006, People's Republic of China.
International journal of nanomedicine
|September 24, 2025
概括
纳米晶体药物递送系统 (NCDDS) 为提高传统中医 (TCM) 自然化合物的临床转化提供了一个有前途的解决方案. 这些系统提高了溶解性,生物可用性和有效性,同时解决了稳定性和制备方面的挑战.
科学领域:
- 药理学和制药科学 药理学和制药科学
- 材料科学 材料科学 材料科学
- 传统中国医药 传统中国医药
背景情况:
- 传统中医 (TCM) 提供了几个世纪的治疗价值,但面临着诸如复杂的制备,不良的稳定性和天然化合物的低生物可用性等局限性.
- 来自TCM的天然活性成分,如类和黄类,显示出显著的治疗潜力,但由于溶解性差,生物可用性低和潜在的毒性而受到阻碍.
研究的目的:
- 审查最近纳米晶体药物递送系统 (NCDDS) 对TCM衍生的天然化合物的进展.
- 详细阐述NCDDS用于类,黄类和多的制备技术,表征方法和疗效增强.
- 确定NCDDS在加快TCM天然产品临床转化方面的持续挑战和未来机会.
主要方法:
- 对自然化合物的NCDDS最近研究的综合.
- 对纳米晶体的制备技术和表征方法的阐述.
- 通过使用NCDDS进行体外和体内自然剂的疗效增强的分析.
主要成果:
- NCDDS在增强药物溶解,提高生物可用性和实现自然化合物的向输送方面取得了成功.
- 最近的进展表明,在NCDDS中封装的类,黄类和多类的体外和体内疗效有所改善.
- 尽管取得了进展,但合体稳定性,生产可扩展性和长期毒性等挑战仍然存在.
结论:
- NCDDS代表了一种多功能策略,可以克服TCM天然化合物的局限性,促进其临床应用.
- 需要进一步的研究来解决与NCDDS相关的稳定性,可扩展性和毒性问题.
- 未来的方向包括先进的准备技术,多功能修改和跨学科的应用,以加速临床翻译.
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