打破循环:我们应该针对炎症,纤维化,还是两者兼而有之?
Sarah K Baxter1,2, Ricardo A Irizarry-Caro3, Jason A Vander Heiden3
1Sonoma Biotherapeutics, South San Francisco, CA, United States.
Frontiers in immunology
|September 24, 2025
概括
针对系统性硬化 (SSc),异常性肺纤维化 (IPF) 和类风湿性关节炎 (RA) 等慢性疾病的炎症或纤维化是关键. 了解免疫和纤维化之间的相互作用对于开发有效的治疗方法来恢复组织功能至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
- 肺部病理学 肺部病理学
背景情况:
- 慢性炎症和自身免疫性疾病可能导致不可逆转的纤维化,损害器官功能.
- 最佳的治疗策略 (向炎症,纤维化或两者兼而有之) 仍然是疾病管理的关键问题.
- 间歇性肺病 (ILD) 为研究炎症-纤维化相互作用提供了一个模型.
研究的目的:
- 探索肺部疾病中炎症和纤维化之间的关系.
- 评估针对系统性硬化症 (SSc),异常性肺纤维化 (IPF) 和类风湿性关节炎 (RA) 的细胞因子通路和B淋巴细胞的治疗策略.
- 确定恢复组织平衡和改善功能结果的潜在途径.
主要方法:
- 对人类ILD组织的临床和转化研究的审查.
- 对涉及免疫细胞 (巨细胞,B细胞) 在纤维生成中的分子和蛋白质组数据的分析.
- 检查了针对细胞因子通路和B淋巴细胞的分子干预的数据.
主要成果:
- 免疫系统的组成部分,包括特定的巨细胞群和产生自身抗体的B细胞,都与纤维生成有关.
- 针对细胞因子通路和B淋巴细胞的干预措施显示出调节临床,功能,细胞和分子结果的潜力.
- 人类疾病中炎症和纤维化之间的机制联系开始被阐明.
结论:
- 了解炎症和纤维化之间的相互作用对于开发向疗法至关重要.
- 为了优化治疗策略,还需要进一步的细粒度临床结果,生物标志物数据和试验标准化.
- 未来的研究可能会导致改善治疗方法,以恢复组织平衡,并保持器官功能在纤维化的疾病.
相关概念视频
01:28Inflammatory Response
16.0K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
16.0K
01:24Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
492
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
492
01:29Inflammatory Bowel Disease IV: Pharmacological Management
521
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
521
01:09Introduction to Fibroblasts
3.8K
Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
3.8K
01:38Inflammation
61.7K
Overview
61.7K
02:17The Tumor Microenvironment
7.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.6K