炎症性肠道疾病中的肠道菌群:对案例对照研究的系统审查
Johannes D Füchtbauer1,2,3, Olga Brovkina4, Kostas Sivickis4
1Department of Medical Gastrointestinal Diseases S, Odense University Hospital, Odense, Denmark.
Inflammatory bowel diseases
|September 24, 2025
概括
在炎症性肠道疾病 (IBD) 中,肠道菌组发生变化. 在IBD患者和对照人群中,菌β多样性始终不同,克罗恩病中观察到Candida和Malassezia的增加.
科学领域:
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
- 免疫学 免疫学 免疫学
背景情况:
- 炎症性肠病 (IBD) 研究主要集中在细菌肠道组成上.
- 在IBD中,肠道微生物组或真菌微生物组仍未得到充分研究.
- 抗Saccharomyces cerevisiae抗体是克罗恩病 (CD) 的已知生物标志物,但不是性结肠炎 (UC).
研究的目的:
- 系统地审查和综合有关IBD人类肠道菌群的当前知识.
- 确定与IBD相关的真菌微生物群落的一致变化.
- 突出未来的真菌生物组研究需要标准化.
主要方法:
- 对病例控制研究的系统审查.
- 在EMBASE和MEDLINE数据库中进行的搜索.
- 对27项涉及1406名IBD患者和1060名对照者的研究进行了分析.
主要成果:
- 阿尔法多样性的差异是不一致的,并且受到地理影响.
- 在IBD病例和对照人群之间一致观察到贝塔多样性差异.
- 在CD和UC中发现Candida的增加;马拉塞西亚在CD中增加,通常与Saccharomyces的减少有关.
结论:
- 在IBD中,肠道菌群被持续改变,特别是在β多样性中.
- 样本采集,分析和数据处理的标准化对于未来的研究至关重要.
- 调查以前没有接受过治疗的患者和症状对照将推动这一领域的发展.
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