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双阶段药物输送微球通过凝固增强的血管封闭扩大瘤饥饿

Kexin Wen¹, Yingjie Ren¹, Junjun Huang¹

¹Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medicine Sciences, Jinan, Shandong, 250117, P. R. China.

Small (Weinheim an der Bergstrasse, Germany)

|September 24, 2025

概括

这项研究开发了响应pH的微球,以增强瘤饥饿疗法. 微球共同提供诱导血液凝固的药物,显著提高抗瘤功效并减少转移.

科学领域:

生物材料科学生物材料科学
癌症治疗癌症治疗
药物输送系统药物输送系统

背景情况:

瘤饥饿疗法面临来自不完全血管封闭和瘤代谢适应的挑战.
有效的营养剥夺需要对瘤血管系统进行强有力的持续破坏.
需要新的策略来克服瘤饥饿治疗中的抵抗机制.

研究的目的:

开发一个pH响应的微球系统,用于协同的瘤饥饿疗法.
为了同时提供一种血管干扰剂和一种促凝剂,以增强瘤血管封闭.
调查开发系统的治疗疗效和抗转移潜力.

主要方法:

制造多孔的多乳-co-甘油酸 (PLGA) 微球,嵌入具有pH响应的碳酸 (CaCO3) 纳米颗粒.
在微球中同时封装5,6-二甲基甘-4-酸 (DMXAA) 和血栓.
在体外评估由酸性瘤微环境触发的连续药物释放.
在B16F10黑色素瘤和4T1乳腺癌小鼠模型中的治疗功效的体内评估.

主要成果:

工程微球显示了pH响应的DMXAA和血栓蛋白的顺序释放.
加入CaCO3增强了药物负载,并为凝固提供了Ca2+离子.
在B16F10模型中观察到显著的瘤生长减缓和血管血栓形成.
在4T1模型中,有效地缓解了原发性瘤生长和肺转移.

结论:

开发的多功能微球为协同瘤饥饿疗法提供了一个有前途的战略.
连续的药物释放和诱导的血管内凝血增强了抗瘤功效.
该系统显示了对初级瘤控制和减少转移性传播的潜力.

关键词:

级联放大级别的放大.血管内凝血是指血管内凝血.这些微球是微球.顺序释放药物的药物释放.瘤饥饿疗法是一种治疗方法.

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