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开发和初步内容验证的新版本的损害指数在血栓性抗脂综合征 (DIAPSV2) 的损害指数
María Victoria Goycochea Robles1, Gabriela Medina García2, Claudia Mendoza Pinto3
1Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Lupus
|September 24, 2025
概括
为了更好地量化APS患者的慢性损伤,开发了新版本的血栓抗脂综合征损伤指数 (DIAPSv2). 这个更新的索引包括11个领域的32个项目,以提高准确性.
科学领域:
- 类风湿病学 类风湿病学
- 血液学 血液学 血液学
- 临床流行病学临床流行病学
背景情况:
- 抗脂综合征 (APS) 是获得高凝血的主要原因,导致血栓事件和产科问题.
- 精确量化APS慢性损伤对于有效的患者管理至关重要.
- 原始的血栓性APS损害指数 (DIAPS) 需要更新以提高全面性和特异性.
研究的目的:
- 为了详细说明修订后的损害指数的内容验证过程,请参阅 DIAPSv2.2.
- 改进对血栓性APS慢性损伤的评估.
- 改善诊断特异性和患者管理策略.
主要方法:
- 在两个阶段采用了经过修改的Delphi面板方法.
- 第1阶段涉及对现有DIAPS研究进行系统范围审查.
- 第二阶段利用了三轮专家共识,最终确定了DIAPSv2项目和定义.
主要成果:
- 原始的DIAPS显示有效性,但缺乏某些慢性损伤指标,如气囊出血.
- 专家的共识导致评估了41个建议项目,其中32个最终被纳入DIAPSv2.2.
- 根据专家输入和国际指南,更新了项目定义.
结论:
- DIAPSv2是通过一个协作,多学科的共识过程来开发的.
- 新的索引包含11个域和32个项目,改进了原来的10个域和38个项目.
- DIAPSv2提供了一种更具体的工具,用于评估血栓性APS患者的不可逆转损伤.
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