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评估EQUAL Candida评分的预后价值和基于候群病相关死亡率的诺莫格拉姆方法

Elif Mukime Saricaoglu¹, Melike Inan Hekimoglu¹, Ezgi Gulten¹

¹Ankara University Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Ankara, Turkey.

|September 24, 2025

概括

EQUAL Candida 评分有效预测患有白血病 (一种严重的血液感染) 的患者的死亡风险. 12分或更高的得分表明更好的生存率,有助于早期风险分层.

科学领域:

医学真菌学医学真菌学
传染性疾病传染性疾病
临床流行病学临床流行病学

背景情况:

尽管抗真菌疗法取得了进展,但 kandidemia 存在高死亡风险.
EQUAL Candida 评分是为了标准化准则的遵守而开发的,但需要进一步的预后验证.
这项研究评估了遵循指南的临床影响以及EQUAL Candida评分对候选病死亡率的预测价值.

研究的目的:

评估EQUAL Candida评分在预测白血病患者死亡率方面的预后价值.
为了确定是否遵守指导方针,以EQUAL Candida评分来衡量,影响患者的结果.
为了开发和验证一个预后的候选性病死亡风险分层的预后 nomogram.

主要方法:

成年候选血病患者的回顾性队列研究.
根据90天死亡率将患者分为幸存者和非幸存者.
多变量考克斯回归分析,以确定死亡率和名谱发育的独立预测因素.

主要成果:

总共有189名患者被纳入; 46.6%的患者在90天内死亡.
较低的EQUALCANDIDA分数与较高的死亡率有关 (中位数为8对13,p<0.001).
死亡率的独立预测因素包括免疫抑制治疗,败血症休克,缺乏源控制和EQUAL分数<12. 开发了一个预后名录,并进行了外部验证.

结论:

EQUAL Candida 评分是一个可靠的候选血病预后标志物.
将EQUAL Candida评分与临床参数结合起来,可以改善死亡风险估计.
开发的诺米图为早期风险分层和优化高风险患者管理提供了一个实用的工具.

关键词:

在EQUAL分数中,分数是等的.候选血病是什么意思候选血病是什么意思准则的坚持准则的坚持死亡率死亡率这个名字是名ogramogram.预后因素预后因素风险预测风险预测

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