相关实验视频

Updated: Jan 17, 2026

Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer

Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer

Published on: January 17, 2025

在胰腺瘤微环境中准PIN1与片两释放免疫检查点治疗

Yuanyuan Wu^1,2,3,4, Jianan Guo^1,2,3,4, Yuwei Zhang^1,2,3,4

¹Department of Hepatobiliary Surgery I, General Surgery Center, Zhujiang Hospital, Southern Medical University, Guangzhou, China.

Advanced healthcare materials

|September 24, 2025

概括

一个新的纳米粒子将KPT-6566传递给胰腺癌细胞和胰腺星状细胞,通过重编程瘤微环境和阻断PD-L1.1,增强免疫疗法. 这种双重向的方法旨在改善胰腺癌治疗结果.

科学领域:

在瘤学瘤学.
纳米技术纳米技术
免疫治疗是一种免疫疗法.

背景情况:

胰腺癌 (PC) 由于其侵略性和有限的治疗选择,预后不佳.
激活的胰腺恒星细胞 (PSC) 和胰腺癌细胞 (PCC) 形成纤维化屏障和免疫抑制瘤微环境 (TME),阻碍治疗的有效性.
需要采用双重准策略,同时准PCC和PSC,以改善PC处理.

研究的目的:

开发一种基于的纳米颗粒 (DP-KPT-CG@PA) 来同时输送KPT-6566和一种PD-L1阻断.
为了研究纳米粒子向PCC和PSC的能力,使激活PSC (aPSC) 恢复静止状态,并抑制PCC扩散.
评估纳米粒子和PD-L1阻断对增强胰腺癌免疫疗法的协同效应.

主要方法:

设计和合成两种两性:C16-LLGG-COO-^DPPA-1 (DPPA-1@PA) 和DSPE-PEG-NHS-CGKRK (CGKRK@PA) 的设计和合成.
的联合组装以封装KPT-6566,形成基于的纳米粒子DP-KPT-CG@PA.
评估纳米粒子的准能力,对PCC和PSC的治疗效果,以及瘤免疫微环境 (TIME) 中的免疫重编程.

主要成果:

实际上,DP-KPT-CG@PA纳米粒子与KPT-6566一起提供,以针对PCC和PSC.
KPT-6566重新编程了TIME,提高了抗PD-L1免疫疗法的疗效.
纳米粒子抑制PCC增殖并诱导PD-L1表达,增加对PD-L1向疗法的敏感性.

结论:

开发的基于的纳米粒子为胰腺癌提供了一个有前途的双重向策略.
通过DP-KPT-CG@PA同时提供KPT-6566和PD-L1阻塞可以提高抗瘤疗效和免疫治疗反应.
这种方法有可能改善胰腺癌患者的治疗结果.

关键词:

两类酸是两类的.结合免疫疗法组合免疫疗法共同组装纳米粒子药物输送是药物输送的过程.胰腺癌是一种癌症.

更多相关视频

Ultrasound-Guided Orthotopic Implantation of Murine Pancreatic Ductal Adenocarcinoma

Ultrasound-Guided Orthotopic Implantation of Murine Pancreatic Ductal Adenocarcinoma

Published on: November 19, 2019

Generation of Orthotopic Pancreatic Tumors and Ex vivo Characterization of Tumor-Infiltrating T Cell Cytotoxicity

Generation of Orthotopic Pancreatic Tumors and Ex vivo Characterization of Tumor-Infiltrating T Cell Cytotoxicity

Published on: December 7, 2019

相关概念视频

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...