一种基于DNA甲基化的新型替代生物标志物用于慢性系统性炎症 (炎症潜变甲基化替代物,InfLaMeS)
Helen C S Meier1, Eric T Klopack2, Mateo P Farnia3
1Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, USA.
概括
一种新的DNA甲基化 (DNAm) 替代生物标记物InfLaMeS准确地预测炎症和相关的健康结果,如死亡率和残疾. 这种生物标志物提供了一个强大的替代品,当直接的炎症措施是不可用的.
科学领域:
- 生物医学研究的研究.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 老年学是一门学科.
背景情况:
- 慢性低度系统性炎症是慢性疾病,死亡率和衰老的关键风险因素.
- 替代生物标志物DNA甲基化 (DNAm) 可以预测健康结果,当直接措施是不可行的.
- 评估炎症的现有方法通常需要直接测量炎症标志物.
研究的目的:
- 开发和验证一种DNAm替代生物标志物用于慢性系统性炎症.
- 评估这个替代生物标志物在预测年龄相关健康结果方面的表现.
- 评估其作为传统炎症标记物的替代品的实用性.
主要方法:
- 从7个炎症标记的潜在变量生成了一个DNAm替代生物标记物 (InfLaMeS).
- 评估了 InfLaMeS 与个别炎症标志物之间的相关性.
- 在健康和退休研究 (HRS) 中评估了InflaMeS与多病症,残疾和死亡率的关联.
- 在爱尔兰长度老龄化研究 (TILDA) 中验证的结果.
主要成果:
- InfLaMeS生物标志物与个体炎症标志物有显著的相关性 (r = -0.20.6).
- 与HRS中测量的潜在炎症变量相比,InfLaMeS与多重疾病,残疾和4年死亡率具有相似或更强的关联.
- 结果在独立队列 (TILDA) 中成功验证.
结论:
- InfLaMeS作为一种强大的DNAm基替代体,用于系统性炎症.
- 这种生物标志物是研究的有价值的替代品,当直接的炎症标志物数据不存在,但DNAm数据可用时.
- 在预测与炎症相关的健康结果和死亡率方面,InflaMeS具有广泛的适用性.
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