淋巴缺血作为临床COVID-19的诊断生物标志物:对SARS-CoV-2变种的综合研究的见解
R Uppal1, U Saeed2,3, R Tahir4
1Islamabad Diagnostic Center - IDC, Department of Research and Development, Islamabad, Pakistan.
Brazilian journal of biology = Revista brasleira de biologia
|September 24, 2025
概括
血液学异常在COVID-19患者中很常见,淋巴细胞数量减少表明早期诊断的潜力. 这一发现支持使用淋巴细胞衰减作为一个具有成本效益的生物标志物,特别是在资源有限的环境中.
科学领域:
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
- 临床诊断 临床诊断 临床诊断
背景情况:
- 由于COVID-19的流行,需要有效的工具来评估疾病的严重程度.
- 血液学参数可以提供有关SARS-CoV-2感染的见解.
研究的目的:
- 为了调查疑似SARS-CoV-2受试者的血液学异常.
- 评估淋巴细胞衰减作为COVID-19早期诊断标记物的潜力.
主要方法:
- 从2021年1月到2022年8月的大量数据集 (142,133个样本) 的分析.
- 确认SARS-CoV-2阳性和阴性个体之间的血液学参数的比较.
- 评估各种血细胞计数和炎症标志物.
主要成果:
- 确诊的COVID-19患者,特别是患有Omicron和Centaurus变种的患者,与阴性参与者 (27.01%) 相比,血液学异常的频率更高 (30.42%).
- 在40.95%的阳性病例中观察到淋巴细胞数量减少 (淋巴细胞减少),这表明其具有诊断效用.
- 阳性患者的淋巴细胞,中性粒细胞,乙氨基粒细胞,单细胞,红细胞,中性粒细胞与淋巴细胞的比率,C反应蛋白和D-二次体的异常数量显著增加.
结论:
- 淋巴细胞衰竭是临床COVID-19的潜在的成本效益和早期诊断生物标志物.
- 这一发现特别适用于资源有限的环境,有助于战略选和政策制定.
- 血液学评估可以补充SARS-CoV-2的现有诊断方法.
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