通过触发JAK/STAT通路,SNORA33促进清细胞细胞癌的发展和对苏尼提尼布的抗性
Jiajia Sun1, Shuo Zhao1, Xiaochen Ren1
1Department of Urology, Qilu Hospital of Shandong University, Jinan, Shandong, China.
IUBMB life
|September 24, 2025
概括
在清细胞细胞癌 (ccRCC) 中,SNORA33的高度表达,促进瘤的进展和抗苏尼替尼的耐药性. 这种小核RNA (snoRNA) 可能作为ccRCC免疫疗法预测的生物标志物.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 小核RNAs (snoRNAs) 在各种癌症中发挥作用.
- 在清细胞细胞癌 (ccRCC) 中SNORA33的特定功能尚不清楚.
研究的目的:
- 研究SNORA33在ccRCC瘤发生和进展中的作用和机制.
- 评估SNORA33作为ccRCC免疫治疗的潜在生物标志物.
主要方法:
- 分析来自TCGA和SNORic数据库的snoRNA表达数据.
- 卡普兰-梅尔分析和考克斯回归用于预后价值.
- 在体外实验中评估SNORA33在ccRCC细胞中的功能.
- 基因组丰富分析 (GSEA) 和西方布洛特 (Western Blot) 研究基因组丰富分析的机制.
主要成果:
- 在ccRCC中SNORA33的表达很高,并与预后不佳有关.
- SNORA33与免疫细胞透,免疫分数和免疫检查点分子相关联.
- 实验室研究表明,SNORA33促进了ccRCC的扩散,入侵,迁移和苏尼替尼抗性.
- 在ccRCC进展中,SNORA33调解了JAK/STAT通路.
结论:
- SNORA33是ccRCC进展,入侵,转移和耐药性的关键驱动因素.
- 在ccRCC患者中,SNORA33作为预测免疫治疗反应的潜在生物标志物.
- 针对SNORA33或JAK/STAT通路可能为ccRCC提供治疗策略.
更多相关视频
10:21Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
Published on: September 20, 2024
719
13:19Quantifying Antibody-Dependent Cellular Cytotoxicity in a Tumor Spheroid Model: Application for Drug Discovery
Published on: April 26, 2024
3.8K
相关概念视频
mTOR Signaling and Cancer Progression
4.6K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
4.6K
Abnormal Proliferation
5.1K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.1K
The JAK-STAT Signaling Pathway
12.1K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
12.1K
PI3K/mTOR/AKT Signaling Pathway
5.4K
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a...
5.4K
The Retinoblastoma Gene
4.7K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.7K
Non-Canonical Wnt Signaling Pathways
8.3K
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
8.3K
