基于尿液的PET/NIRF双模成像用于精确的瘤诊断和手术
Linjie Bian1,2,3, Panli Li1,2,3,4, Yigang Chen5
1Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
European journal of nuclear medicine and molecular imaging
|September 24, 2025
概括
一个新的双模式成像平台的目标是平衡核酸载体1 (ENT1) 介导的尿素运输,以提高癌症检测. 这种方法有助于精确的瘤成像和手术导航,提高诊断准确性和治疗结果.
科学领域:
- 在瘤学瘤学.
- 分子成像学分子成像学
- 生物化学 生物化学
背景情况:
- 癌细胞表现出代谢重编程,以生存营养缺乏.
- 尿素对胺代谢,核酸合成和氧化还原平衡至关重要.
- 缺乏用于平衡核酸载体1 (ENT1) 介导的尿液输送的高灵敏度成像工具,阻碍了精确的癌症诊断和外科指导.
研究的目的:
- 开发和验证一种针对ENT1介导的尿液输送的新型双模成像平台.
- 为了实现精确的瘤成像和手术内外科导航.
主要方法:
- 合成了用于PET的[68 Ga]Ga-DOTA-FZUD和用于NIR-II光成像的ICG-FZUD.
- 在各种癌症模型中进行小动物PET/CT和NIR-II光成像.
- 人胃癌手术样本的体外成像,以确认瘤向.
主要成果:
- 在胰腺,胃,乳腺和质母细胞瘤中,Ga-DOTA-FZUD在具有更高ENT1表达的模型中显示出高瘤吸收率.
- ICG-FZUD提供了高对比度的NIR-II成像,清楚地界定了瘤边缘,并穿透了血脑屏障.
- 活体分析证实了人类胃癌组织的选择性瘤吸收,与其组织病理相关.
结论:
- 针对ENT1的尿液输送PET/NIRF双模成像平台为基于葡萄糖的成像提供了替代方案.
- 这个平台提供实时的操作内导航功能.
- 它显示了早期癌症诊断,精确手术的显著前景,并具有强大的翻译潜力.
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