在印度曼加卢鲁分离的皮肤植物中发现了耐药性和毒性特征
Apoorva R Kenjar1, Banavasi Shanmukha Girisha2, Jyothi Jayaraman3
1Department of Infectious Diseases and Microbial Genomics, Nitte University Centre for Science Education & Research, Kankanady, Mangaluru, Karnataka, India.
The Indian journal of medical research
|September 24, 2025
概括
皮肤菌感染很常见,并导致严重的痛苦. 这项研究发现,在反复性病例中,抗真菌耐药性和特定基因突变的高率,突出显示了持续监测的必要性.
科学领域:
- 医学真菌学 医学真菌学
- 皮肤病学 皮肤病学
- 传染性疾病 传染性疾病
背景情况:
- 皮质植物导致全球普遍的真菌性皮肤感染,影响生活质量.
- 了解皮肤植物病原性,包括毒性因素和耐药性,对于反抗性病例至关重要.
研究的目的:
- 为了调查皮肤植物在反复性 tinea 感染的流行情况.
- 分析这些分离物中的抗真菌易感性,烯环氧化酶基因突变和毒性因子.
主要方法:
- 这是一项基于医院的前性研究,对93名患有反抗性 tinea 感染的人进行了研究.
- 包括标准:临床诊断的皮肤植物病;排除标准:糖尿病,免疫抑制疗法.
- 方法包括真菌培养,ITS测序,抗真菌敏感性测试,烯氧化酶基因突变分析和毒性因子测定.
主要成果:
- 在70.96%的样本中发现了皮肤菌,其中Trichophyton mentagrophytes复合体是最常见的.
- 可纳,特比纳和伊特拉可纳的高最低抑制度 (MIC) 表明了体外耐药性.
- 在六个分离物中发现了烯环氧化酶基因的错误突变,以及高水平的酶生产水平.
结论:
- 这些发现凸显了皮肤植物病的复杂性和抗真菌耐药性的日益挑战.
- 持续追踪抗真菌耐药性模式和毒性因素对于有效的治疗策略至关重要.
- 在抗真菌耐药性日益增加的情况下,洞察力对于改善患者的治疗结果至关重要.
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