父母精神障碍和子女死亡率,直到中年
Hui Wang1,2, Krisztina D László1,3
1Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden.
JAMA psychiatry
|September 24, 2025
概括
父母患有精神障碍的孩子面临着死亡风险翻倍的风险,直到51岁. 这种增加的风险,特别是非自然死亡的风险,凸显了对家庭支持系统的需求.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 精神病学是一个精神病学.
背景情况:
- 父母精神障碍与婴儿死亡率和发育问题有关.
- 患有精神障碍的父母后代的长期死亡风险在很大程度上是未知的.
研究的目的:
- 调查父母精神障碍与子女死亡风险到中年之间的关联.
主要方法:
- 全国瑞典基于登记的队列研究 (1973-2014年出生).
- 从患者登记册中确定了父母的精神障碍.
- 分析后代死亡率 (任何,自然,非自然原因) 使用考克斯比例危险模型和表亲比较分析.
主要成果:
- 暴露于父母精神障碍的后代有2.13倍的全因死亡风险.
- 观察到自然 (HR 1.88) 和非自然原因 (HR 2.45) 的死亡风险增加.
- 所有主要的父母精神障碍类型都与子女死亡率的增加有关,智力障碍最强.
结论:
- 父母精神障碍显著增加后代的死亡风险,直到51岁.
- 这种关联在非自然死亡和父母都患有精神障碍时是最强的.
- 调查结果强调,需要为父母患有精神障碍的家庭提供支持,以减轻过早死亡风险.
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