晒伤和皮肤状细胞癌:一个元分析
Isaac Weber1, Kaiping Liao1, Tran Dang2
1Department of Health Services Research, The University of Texas MD Anderson Cancer Center, Houston.
JAMA dermatology
|September 24, 2025
概括
病史有疼痛,水泡或严重的晒伤,可显著增加患皮肤状细胞癌 (cSCC) 的风险. 这包括童年和终身的晒伤,强调了防晒的重要性.
科学领域:
- 皮肤病学和瘤学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 紫外线 (UV) 辐射是已知的致癌物,与皮肤状细胞癌 (cSCC) 有关.
- 晒伤史对cSCC风险的具体贡献需要进行定量评估.
研究的目的:
- 量化评估日晒病史与患上cSCC的风险之间的关联.
- 综合来自多项研究的证据,以提供对这种关联的可靠估计.
主要方法:
- 在Embase,PubMed和Cochrane图书馆 (CENTRAL) 进行了系统的文献搜索,直到2025年5月.
- 使用随机效应建模 (DerSimonian-Laird方法) 的17项研究 (321,473名参与者) 的元分析.
- 结果:cSCC的风险. 测量:普通晒伤频率 (没有,低,中,高) 和有痛苦,水泡或严重晒伤的病史.
主要成果:
- 中等和高频率的终身疼痛,泡或严重的晒伤与增加的cSCC几率 (OR分别为1.51和1.69) 有显著的关联.
- 儿童日晒的高频率与cSCC几率的增加有很强的关联 (OR 3.11).
- 任何有痛苦,水泡或严重晒伤的病史都与较高的cSCC几率 (OR 1.38) 有关.
结论:
- 这一元分析提供了强有力的证据,支持疼痛,水泡或严重的晒伤与cSCC风险增加之间的关联.
- 这些发现强调了为预防cSCC而尽量减少一生中严重晒伤的重要性.
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