软饮料消费和抑郁症由肠道微生物组变化介导
Sharmili Edwin Thanarajah1,2,3,4, Adèle H Ribeiro5, Jaehyun Lee1,4
1Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt-Goethe University, Frankfurt am Main, Germany.
JAMA psychiatry
|September 24, 2025
概括
软饮料的消费与严重抑郁症 (MDD) 有关,并且可能由肠道细菌 (如Eggerthella) 介导. 减少摄入量可能会降低抑郁症的风险,特别是在女性中.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 公共卫生 公共卫生
背景情况:
- 软饮料消费与不良健康结果有关,但与主要抑郁症 (MDD) 的联系和潜在机制尚未完全理解.
- 肠道微生物群的改变越来越多地与心理健康状况有关,但与软饮料摄入量和MDD的具体联系需要进一步调查.
研究的目的:
- 调查软饮料消费与MDD的诊断和严重程度之间的关联.
- 确定肠道微生物群,特别是埃格特拉菌和汉加特拉菌的丰富性,是否调解了软饮料消费和MDD之间的关系.
主要方法:
- 德国的一项多中心队列研究分析了405名患有MDD的患者和527名健康对照者的横截面数据.
- 使用多变量回归和ANOVA模型来评估软饮料消费,MDD和肠道微生物群之间的关联.
- 进行了调解分析,以评估Eggerthella和Hungatella丰度在软饮料-MDD联系中的作用.
主要成果:
- 软饮料消费与MDD诊断的几率增加 (OR,1.081) 和症状严重程度更高 (P < .001) 有关.
- 这些关联在女性中更为明显,她们也表现出更多的Eggerthella丰富度与更高的软饮料摄入量.
- 调解分析证实,埃格特拉菌显著调解了软饮料消费与MDD诊断 (P = .011) 和严重程度 (P = .005) 之间的关系.
结论:
- 通过肠道微生物群的改变,饮用软饮料可能会导致MDD,特别是涉及Eggerthella.
- 减少软饮料摄入量的公共卫生举措可以减轻抑郁症风险,特别是在弱势群体中.
- 针对微生物组合的干预措施显示出治疗抑郁症的前景.
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