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Oroxylum indicum根皮提取物减轻了由乙氨基和西斯普拉丁诱导的肝损伤
Seema Menon1,2, Lincy Lawrence1, Vipin P Sivaram1,3
1Department of Biochemistry and Plant Biotechnology, Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala, India.
Zeitschrift fur Naturforschung. C, Journal of biosciences
|September 24, 2025
概括
奥洛西印基根树皮提取物保护了老鼠免受乙氨基和西斯所引起的肝脏和脏损伤. 这种阿育吠陀植物提取物恢复了氧化还原平衡,减轻了药物诱导的毒性.
科学领域:
- 药理学 药理学是指药理学的学科.
- 毒理学 毒理学 毒理学
- 草药是一种草药.
背景情况:
- 罗西 (Oroxylum indicum) 是来自达萨莫拉群的关键阿育吠陀草药.
- 传统上以其排毒特性而闻名.
- 药物诱导的器官损伤仍然是一个重要的临床问题.
研究的目的:
- 评估Oroxylum indicum根树皮甲醇提取物 (ORX) 对乙氨基诱导的肝毒性的保护作用.
- 评估ORX对西斯普拉丁诱导的毒性和骨髓抑制的疗效.
- 调查潜在的机制,特别是恢复氧化还原平衡.
主要方法:
- 给老鼠注射了乙氨基或西斯来诱导毒性.
- 用Oroxylum indicum根皮提取物 (ORX) 进行预处理,剂量为200 mg/kg和400 mg/kg.
- 分析了肝脏和脏功能的生化标志物.
- 肝脏和脏的氧化应激标志物 (SOD,GPx,GSH,脂质过氧化) 被测量.
- 对肝脏和脏组织进行了组织病理学检查.
主要成果:
- 在乙氨基暴露后,ORX显著降低了血清肝酶 (AST,ALT,ALP) 和胆红素水平的升高 (p < 0.01).
- ORX逆转了乙氨基诱导的肝脏抗氧化剂的枯竭,并增加了脂质过氧化.
- ORX预治疗改善了西斯普拉丁诱导的毒性,骨髓抑制和氧化应激.
- 组织学分析证实ORX使肝脏和脏的结构恢复到正常状态.
结论:
- 奥洛西印基根树皮提取物显示出显著的肝脏保护和脏保护作用.
- 保护机制包括恢复氧化还原平衡和减轻氧化应激.
- 奥洛西印具有作为治疗药物诱导器官损伤的治疗剂的潜力.
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