长期COVID中疲劳和神经肌肉功能:一年后续研究
Isabella da Silva Almeida1,2, Leandro Gomes de Jesus Ferreira1,3, Marco Aurélio Vaz4
1Laboratory of Muscle and Tendon Plasticity, Graduate Program in Rehabilitation Science, Faculdade de Ceilândia, Universidade de Brasília, Brasília, Distrito Federal, Brazil.
PloS one
|September 24, 2025
概括
在SARS-CoV-2感染一年后,严重的COVID-19幸存者由于神经肌肉变化而经历持续的疲劳和减少的身体功能. 中度病例也表现出持久的影响,表明需要针对长期COVID患者制定有针对性的康复策略.
科学领域:
- 神经学 神经学
- 身体生理学 身体生理学
- 康复医学 康复医学 康复医学
背景情况:
- 长期COVID (SARS-CoV-2感染的急性后续) 带来了重大的神经肌肉挑战.
- COVID-19的长期 (一年) 神经肌肉后果,特别是疲劳机制,尚未得到充分理解.
- 这项研究调查了中度或重度COVID-19后一年的神经肌肉功能.
研究的目的:
- 确定严重或中度COVID-19后一年个体的疲劳机制.
- 在COVID-19幸存者和健康对照者之间比较感知疲劳,客观疲劳,功能,肌肉结构和神经肌肉电功能.
主要方法:
- 一项纵向观察性研究跟踪了参与者感染后的一年.
- 评估包括感知疲劳,客观疲劳 (扭矩,扭矩-时间积分),功能,肌肉结构 (回声性) 和电神经肌肉功能 (chronaxie).
- 与18例严重的COVID-19病例,22例中度的COVID-19病例和30例健康对照进行比较.
主要成果:
- 严重的COVID-19幸存者报告说,与对照和中度病例相比,感染后一年的感知疲劳和客观疲劳 (低扭矩和TTI) 较高.
- 严重组表现出功能减弱,肌肉结构受损 (回声性增加) 和电神经肌肉功能改变 (较高的慢性).
- 中度的COVID-19病例显示了疲劳,神经肌肉功能和肌肉结构的变化,特别是在基线.
结论:
- 严重的COVID-19幸存者经历持续疲劳和增加疲劳性感染后一年,表明恢复速度较慢.
- 肌肉骨和神经机制在COVID-19后的疲劳中发挥着至关重要的作用.
- 基于机制的康复策略对于解决长期COVID相关的神经肌肉损伤至关重要.
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