对COVID-19后认知障碍认知康复干预的初步评估:试点随机对照试验
Jacqueline H Becker1, Eric Watson2, Nadia Zubair1
1Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Neuropsychological rehabilitation
|September 24, 2025
概括
认知康复 (CR) 可能有助于改善长期COVID脑雾和认知问题. 这项试点研究显示,与对照组相比,接受适应CR干预的人对认知功能有自我报告的改善.
科学领域:
- 神经学 神经学
- 康复医学 康复医学 康复医学
- 传染性疾病 传染性疾病
背景情况:
- 长期COVID经常导致显著的认知障碍,通常被称为"脑雾",特别是在年轻人中.
- 目前,对于COVID后的认知缺陷没有确立有效的干预措施.
- 这项研究解决了急需有效治疗SARS-CoV-2感染后认知障碍的迫切需要.
研究的目的:
- 调查针对COVID-19后经历认知障碍的人士量身定制的认知康复 (CR) 计划的初步疗效.
- 评估CR对认知功能客观和主观测量的影响.
主要方法:
- 一项试点随机对照试验与18岁以上的参与者进行,这些参与者有SARS-CoV-2感染史和确诊的认知障碍.
- 参与者被随机分配到12周的CR干预组或时间和注意力匹配的对照组.
- 在干预前和干预后两周内使用验证的神经心理测试来评估认知功能.
主要成果:
- 与对照组相比,CR干预组在处理速度,学习,记忆,语言和执行功能的测量方面没有显示任何徒劳的迹象.
- 与对照组相比,CR干预组的参与者报告说,他们的认知功能在主观上有显著的改善.
结论:
- 一种适应的认知康复干预措施显示,它有望改善与长期COVID相关的认知障碍.
- 这些发现支持需要进行更大规模的,最终的试验,以进一步评估CR对COVID后认知缺陷的疗效.
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