疾病负担,诊断途径和治疗模式在患有乙性食道炎的患者:一个现实世界的研究
Christopher Ma1, Ulrike von Arm2, Frank Zerbib3
1Division of Gastroenterology and Hepatology, Departments of Medicine and Community Health Sciences, University of Calgary, Calgary, AB, Canada.
European journal of gastroenterology & hepatology
|September 24, 2025
概括
患有乙性食道炎 (EoE) 的患者面临长时间的诊断延迟,并努力通过当前的治疗来实现缓解. 对EoE进行最佳的疾病控制仍然是一个重要的未满足的需求.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 临床医学 临床医学
背景情况:
- 性食道炎 (EoE) 越来越普遍,但对管理挑战的真实数据很少.
- 了解当前的治疗模式和结果对于改善患者护理至关重要.
研究的目的:
- 评估被诊断患有EoE的患者的人口和临床特征.
- 分析治疗模式和评估现实世界EoE患者队列中的健康结果.
主要方法:
- 五个欧洲国家2009-2019年间诊断的415名EoE患者 (≥12岁) 的回顾性审查.
- 通过活检 (≥15eos/hpf) 确认诊断;在24个月内进行随访内镜检查.
- 从诊断前12个月到最后一次记录收集的人口统计,临床特征,治疗方法和结果的数据.
主要成果:
- 平均诊断延迟时间为3.4年;平均乙素细胞数量为41.4eos/hpf.
- 常见的治疗包括质子抑制剂 (77.1%),局部皮质类固醇 (68.2%) 和饮食修改 (48.4%).
- 观察到持续组织学活性的高率:63.5% (第一个),62.2% (第二个) 和57.6% (第三个) 的内镜.
结论:
- 患有EoE的患者经历了显著的诊断延迟和相当大的疾病负担.
- 传统的非生物疗法在实现最佳疾病控制方面有效性有限.
- 对于更有效的 EoE 管理策略,有明显的未满足的需求.
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