儿童肥胖和过敏性鼻炎:一个元分析
Xinxin Xing1, Sihao Zhu1, Guang Zhou1
1Department of Pediatrics II, the First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China.
Biomolecules & biomedicine
|September 24, 2025
概括
儿童肥胖与过敏性鼻炎 (AR) 总体上没有显著的联系. 然而,在西方国家和特定的诊断标准中存在潜在的关联,需要进一步调查.
科学领域:
- 儿科过敏和免疫学
- 公共卫生和流行病学
- 肥胖问题研究研究
背景情况:
- 过敏性鼻炎 (AR) 是一种常见的儿童疾病,患病率越来越高.
- 肥胖是儿童日益严重的公共卫生问题.
- 研究正在探索肥胖和AR发病率等可修改因素之间的潜在联系.
研究的目的:
- 进行元分析,评估儿童肥胖和过敏性鼻炎之间的多变量调整关系.
- 综合关于这种关联的观察性研究的证据.
主要方法:
- 在PubMed,Embase和Web of Science进行系统的文献搜索.
- 包括观察性研究,对年龄和性别进行多变量调整.
- 随机效应模型用于组合几率比率 (OR) 和95%置信区间 (CI).
主要成果:
- 对15项横截面研究 (569,856名儿童) 的分析发现,儿童肥胖和AR之间没有总体显著的关联 (aOR:1.04,95%CI:1.00-1.09).
- 亚组分析显示,在西方国家 (OR:1.12,95% CI:1.00-1.24) 有显著的关联,但在亚洲国家 (OR:1.04,95% CI:0.97-1.12) 没有.
- 与国家/国际BMI截止值和医生诊断的AR发现了显著的关联,但与第95百分点BMI或基于ISAAC的诊断没有.
结论:
- 虽然儿童肥胖和AR之间的总体联系在统计上并不显著,但小组发现表明在特定的地理区域和诊断环境中存在潜在的关联.
- 这些结果强调了在定义肥胖和AR时考虑方法差异的重要性.
- 建议进行进一步的纵向研究,以澄清这种关系,并为这两种疾病的预防策略提供信息.
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