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Updated: Jan 17, 2026

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
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Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells

Published on: February 21, 2018

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由MECOM进行的CEBPA镇压阻止了分化,从而驱动了侵袭性白血病

Travis J Fleming1,2,3,4, Mateusz Antoszewski1,2,3,4, Sander Lambo1,2,4

  • 1Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA.

Blood
|September 24, 2025
PubMed
概括

研究人员发现,MECOM基因通过阻断细胞分化来驱动具有攻击性的急性髓性白血病 (AML). 针对特定的调节元件可以扭转这种情况,促进AML细胞分化并减少瘤负担.

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